PTPRC and metastatic neoplasm: As shown in Figure 3E, the population of macrophages (CD45+F4/80+ cells) in hepatic metastatic tumors of WT mice was predominantly CD206-positive, while the proportion of CD45+F4/80+CD206+ cells was significantly reduced in the tumors of Cat S-/- mice (13.99 ± 1.45% versus 37.09 ± 2.81% for CD45+F4/80+CD206+ cells, P<0.01) (Figure 3E).