KDM3A and neoplasm: Significantly elevated levels have been reported in several human cancer cells [117] including bladder, lung, hepatocellular [118], prostate [119], colorectal [120] and renal cell carcinoma [121], and treatment of cancer cell lines with siRNA targeting JmjD1A results in significant suppression of proliferation [118], tumor angiogenesis and macrophage infiltration into tumor tissues [117].