Linkage analysis of a large TS pedigree identified the strongest linkage marker (D3S1311) within SAP97 (Verkerk et al., 2006) and a male individual with TS and ASD has been identified with duplication of the SAP97 gene locus (unpublished data), whereas micro-deletion of 3q inclusive of SAP97 is commonly associated with schizophrenia. This evidence concerns the gene DLG1 and schizophrenia.