This however, appears in opposition with the reduced number of excitatory synapses associated with the downregulation of NLGN4X or the LRRTMs in TS (Figure 1) (Ko et al., 2009; Wright and Washbourne, 2011), albeit the recurrent loss/disruption of NRXN1 in TS and ASD infers loss of both excitatory and inhibitory synaptic connections. The gene discussed is NLGN4X; the disease is Timothy syndrome.