Although almost all of these MMPs have been implicated in the enhancement of tumor cell malignance by increasing angiogenesis and tumor invasiveness, MMP-12 has been implicated in the generation of angiostatin, and the mice deficient in MMP-12 showed an enhancement in the development of Lewis lung carcinoma metastases, suggesting TAM-produced MMP-12 as suppressive for the growth and malignance of lung cancer cells [90]. Here, MMP12 is linked to lung cancer.