Elucidating the complex interplay and roles of TGF-β and MMPs in the tumor, including tumor microenvironment, cancer cells, stroma-infiltrating myeloid cells, and ECM interactions, is critical for understanding their participation in the initiation, progression, metastasis, and eventually uncovering potential combinatory therapeutic targets for future treatment of human cancer. Here, TGFB1 is linked to neoplasm.