TGF-β and MMPs may function in a bidirectional regulatory loop associated with cancer development, TGF-β needs to be proteolytically activated by MMPs in order to exert its cellular functions, whereas activated TGF-β in tumors modulates the balance of ECM remodeling by regulating the expression of MMPs and their tissue inhibitors TIMPs [10, 31]. Here, TGFB1 is linked to cancer.