In particular, curcumin protects neuron-like PC12 rat cells and umbilical endothelial cells against Aβ toxicity and reduces tau hyperphsphorylation [12], promotes Aβ uptake from macrophages of AD patients [13], and dose-dependently reduces fibril formation and extension, also destabilizing preformed Aβ fibrils [14–16]. Here, MAPT is linked to Alzheimer disease.