ACAT1 and atherosclerosis: In a previous study, we have found that the ACAT-1 SNP rs1044925 modulated the serum high-density lipoprotein cholesterol (HDL-C) concentration in the hypercholesterolemic subjects [24], suggesting that rs1044925 influences the cellular cholesterol efflux in hypercholesterolemia and plays an important role in the formation of atherosclerosis.