Of these, ∼20% carry mutations in the gene encoding the superoxide dismutase 1 enzyme (SOD1).1 Transgenic mice expressing mutant forms of human SOD1 are used as a model of familial ALS.2 We have defined the gene expression profiles of MNs isolated from the spinal cord of G93ASOD1 transgenic mice at different stages of disease, by combining the use of laser capture microdissection (LCM) and microarray technology. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.