We identified alterations in genes involved in chromatin remodeling (PBRM1, SETD2), oxidative stress (CUL3, SOD2), immune response (CSMD3, SYK), and gamma-aminobutyric acid receptor signaling (GABRD, GABRG1) in lung adenocarcinoma. Here, PBRM1 is linked to lung adenocarcinoma.