PIK3CA and cancer: Of 32 loci shown in Figure 1, seven were found in the Catalogue of Somatic Mutations in Cancer (COSMIC v.65): ERBB4 V840I, PIK3CA G118D, CTNNB1 S37C, TGFBR2 R504W, MECP2 G273V, CDC27 A273G, and PARP4 I1039T.