TGFBR2 and cancer: Recent work has shown that knockdown of the MED-12 subunit confers drug resistance in cancer cell lines by activating transforming growth factor (TGF-βR2) [112]; the activation of TGF-βR2 appears to be a unique function of the MED-12 subunit because other subunits of mediator do not localize outside of the nucleus, suggesting a MED-12-independent function of mediator.