HMGB1 increases the expression of miR-221 and miR-222 in primary cultures of excised papillary lesions and in an established papillary cancer cell line and overexpression of miR-222 and miR-221 caused by HMGB1 increases growth and motility in papillary thyroid cancer cells. Here, HMGB1 is linked to thyroid gland papillary carcinoma.