TGFB1 and liver dysplastic nodule: On the other hand, another group has demonstrated that TGF-β activated Akt in glomerular mesangial cells by inducing miR-200b and miR-200c, both of which target FOG2, an inhibitor of phosphatidylinositol 3-kinase activation [79], suggesting the role of miR-200 family on glomerular mesangial hypertrophy in the progression of DN.