In a review, Swartbol et al. reported that TNF-α was increased during surgery in almost all aneurism series and reached to the peak level in 6 hours, 15 times increased in the ruptured aneurysms versus the intact aneurysms, remained at peak levels for the postoperative 2 days, and increment persisted in those developed MODS [25]. The gene discussed is TNF; the disease is aneurysm.