Hepatomegaly in patients with ages more than 10 years was reported in 34 cases (74%), but in less than 10 years was found in 12 cases (26%) (P-value=0.003).There is no relation between hepatomegaly and the level of ferritin, Hb, gender and splenectomy.There is a significant relation between hepatomegaly with splenomegaly (P-value=0.018), and also with usage of folic acid (0.046). Here, GSTM1 is linked to Splenomegaly.