The downregulation of SOX2 by 6-MITC and I7557 in PANC-1 pancreatic cancer cells harboring mutant K-ras may shed light on elucidating the interaction between SOX2, EGFR, and its downstream KRAS/BRAF and PI3K/AKT pathways. Here, KRAS is linked to familial pancreatic carcinoma.