However, vessels with the morphology of HEVs in non-Hodgkins lymphoma patients expressed LYVE1 and blood vessels during development can express LYVE1, suggesting that the colocalization of PNAd with LYVE1 represents HEVs that have upregulated LYVE1 (136, 137). The gene discussed is LYVE1; the disease is non-Hodgkin lymphoma.