On the other hand, as it has been mentioned above, in the basic animal experiments MI has been produced with no previous hypoxia, no hypoperfusion, no anemia and therefore no high levels of EPO; (Rekhter et al., 1998) hence, It is predictable that externally infused EPO might have protected these animals and had no similarity with the clinical and biochemical state in EPO resistant patients (Bamgbola et al., 2009; Bamgbola, 2012; Chung et al., 2012; Guerrero-Riscos et al., 2012; Mallick et al., 2012; Okonko et al., 2013). This evidence concerns the gene EPO and anemia.