SOD1 and amyotrophic lateral sclerosis: In addition to human tissue affected by neurodegenerative disease, animal models of these diseases also recapitulate elements of metal dyshomeostasis; AD model mice that over-express the amyloid-β precursor protein have decreased levels of copper and zinc in the brain relative to wild-type controls (Maynard et al., 2002) copper and iron are altered in the brains of PD model mice (Matusch et al., 2010; Ayton et al., 2013) and zinc and copper levels are altered in mutant SOD1 mouse models of ALS (Kiaei et al., 2004; Tokuda et al., 2013).