MAPT and columnar cell hyperplasia of the breast: However, the GSK-3β phosphorylation sites of tau were hyperphosphorylated rather than hypophosphorylated in the CCH mouse brains, suggesting that other opposing factors, such as reduction of O-GlcNAcylation and probably activation of some other tau kinases, had counteracted the effect of GSK-3β inhibition on tau phosphorylation after CCH.