Although insulin administration in STZ treated mice completely (Planel et al., 2007b), or partially (Clodfelder-Miller et al., 2006; Jolivalt et al., 2008) rescued Tau phosphorylation in mice, these findings are in contrast with human studies that report a higher risk of AD in patients treated with insulin (Ott et al., 1999; Luchsinger et al., 2001). Here, MAPT is linked to Alzheimer disease.