In this context, it was demonstrated that treatment with insulin sensitizers (e.g., liragultide, pioglitazone) ameliorates central insulin resistance (Han et al., 2013; Hu et al., 2013; Yang et al., 2013), improves cognitive impairment (Han et al., 2013), enhances synaptic plasticity (Han et al., 2013), and significantly decreases levels of Tau phosphorylation in the rat brain (Hu et al., 2013; Yang et al., 2013). This evidence concerns the gene INS and Insulin resistance.