Interestingly, a recent study has demonstrated that HFD potentiated Tau pathology in a mouse model of Tauopathy, in a manner independent from insulin resistance, suggesting that other factors, probably linked to obesity, might be implicated in Tau pathology during T2DM (Leboucher et al., 2012). The gene discussed is MAPT; the disease is obesity due to melanocortin 4 receptor deficiency.