INS and neuroblastoma: Thus, short insulin treatment (<2–3 min), either in rat primary cortical neurons (Lesort and Johnson, 2000), or in SH-SY5Y human neuroblastoma cells (Lesort et al., 1999), leads to a rapid and transient Tau hyperphosphorylation at the AT8 (Ser202/Thr205), AT180 (Thr231), PHF-1 (Ser396/Ser404) and T3P (Ser396) epitopes (Lesort et al., 1999; Lesort and Johnson, 2000).