For example, Jung et al. have reported an increase in Tau phosphorylation at the Tau-1, Thr212 (Jung et al., 2011, 2013), Thr231, Ser262 and Ser396 (Jung et al., 2013) epitopes in the chronic Otsuka Long Evans Tokushima Fatty (OLETF) T2DM rat model, and these changes were further increased with age (Jung et al., 2013). Here, MAPT is linked to type 2 diabetes mellitus.