A notable example is the evolutionarily conserved neural-expressed miR-125b, which targets both VAChT and AChE-R (Table 2) and associates with all five groups: inflammation and anxiety (Manca et al., 2011; Xu et al., 2011; Danielsson et al., 2012; Matsukawa et al., 2013), brain damage (Rink and Khanna, 2011), neurodegenerative diseases (Lukiw and Alexandrov, 2012) and cardiac diseases (Voellenkle et al., 2010) and diverse pain syndromes (Imai et al., 2011; Kynast et al., 2013; Monastyrskaya et al., 2013; Sakai et al., 2013). This evidence concerns the gene SLC18A3 and neurodegenerative disease.