GBA1 and Gaucher disease: GBA transcript levels were reduced in Gaucher disease lines with N370S/203insC (Patient GD4, median 30% of control, Mann-Whitney U test P = 0.001), N370S/c1263del55 (Patient GD1, median 66% of control, P = 0.007) or N370S/L444P (Patient GD5 median 56% of control, P = 0.001) mutations and in Parkinson’s disease with L444P (Patient PD3 median 42% of control, P = 0.001) or RecNcil (Patient PD4, 55% of control, P = 0.007) mutations (Fig. 1).