Transcripts for the lysosomal proteins hexosaminidase subunit A, aspartyl glucosaminidase, cathepsin K, SCARB2/LIMP2 and iduronidase alpha all rose significantly in control, Gaucher disease and Parkinson’s disease with GBA mutation cells after ambroxol treatment (Supplementary Table 3). The gene discussed is SCARB2; the disease is Parkinson disease.