TFEB transcript levels rose significantly after ambroxol treatment in control (2.25-fold increase, Mann-Whitney U-test P = 0.02), Gaucher disease (2.5-fold increase, P = 0.01) and Parkinson’s disease with GBA mutation fibroblasts (1.75-fold increase, P = 0.03) (Fig. 8). The gene discussed is TFEB; the disease is Gaucher disease.