Although CNI of ACTN4 was dominantly recognized in salivary gland carcinoma with invasive phenotypes, it was recognized in only one of 21 cases with ADCC; therefore, we considered the possibility that, due to the overexpression of actinin-4 that was frequently observed in ADCC patients, protein expression is not correlated to an unfavorable prognosis in salivary gland carcinoma. The gene discussed is ACTN4; the disease is salivary gland carcinoma.