MAPT and supranuclear palsy, progressive, 1: Likewise, immunohistological evaluation of the pons (left, top panel of Figure 3) and striatum (left, bottom panel of Figure 2) in PSP patients revealed that, despite the presence of tau globose tangles, there was no detectable THK523 fluorescence signal in the same region of the adjacent serial brain section, again suggesting that THK523 does not bind to globose tangles.