MAPT and Alzheimer disease: Tau aggregation in this wide spectrum of tauopathies presents with different morphologies (for example, NFTs in AD, astrocytes in CBD, globose tangles and thorny and tufted astrocytes in PSP and Pick bodies in PiD [6-9]) and ultrastructural conformations (for example, paired helical filaments in AD, straight filaments in PSP and twisted ribbons and random coils in PiD [6,10,11]), which are probably attributable to the combinations of the different tau isoforms and a wide variety of posttranslation modifications [6,12].