MAPT and supranuclear palsy, progressive, 1: Tau aggregates are a pathological trait of not only AD but also other neurodegenerative conditions, such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), as well as some variants of frontotemporal lobar degeneration (FTLD-tau) [5], such as Pick’s disease (PiD).