Furthermore, we used in vitro human EC model to elucidate HG, indeed, can result in down-regulation of Gas6/Axl signaling then cause endothelial dysfunction with decrease of cell viability and angiogenesis and induction of monocyte-EC adhesion might be through suppressing VEGF/VEGFR2 expression and activating adhesion molecules. Here, VEGFA is linked to endothelial dysfunction.