This is of particular interest considering that, while in EBV-negative BL the translocated and over-expressed MYC plays a key role in TERT activation, in EBV-positive diffuse large B-cell Lymphomas and immunoblastic lymphomas where MYC is in germ-line configuration, TERT is likely to be activated by LMP-1, as it occurs in LCLs [28]. This evidence concerns the gene MYC and diffuse large B-cell lymphoma.