In addition to over expression of p16INK4A as potential surrogate marker of HPV-derived squamous cell carcinomas, the development of SCCC in HIV positive patients has been documented to involve activation of epidermal growth factor receptor (EGFR) and its phosphorylated form (p-EGFR) [48-50]. The gene discussed is CDKN2A; the disease is squamous cell carcinoma.