Several studies have discussed about the optimal method for determining HPV status on FFPE tumor sections (5, 34, 35), and in the current study, we evaluated immunohistochemical expressions of p16INKA, EGFR and p-EGFR IHC as markers of HPV status and utilized HPV PCR in a subset of cases to correlate the results. The gene discussed is EGFR; the disease is neoplasm.