TTR and polyneuropathy: In November 2011, the European Medicines Agency[10] approved tafamidis meglumine, a small molecule that stabilizes and inhibits the dissociation of circulating TTR tetramers, thus preventing the deposition and formation of the abnormal TTR fibrils, for TTR-FAP Val30Met patients with stage-1 polyneuropathy, and it seems to be very promising[11,12].