Among subjects with acute ischemic stroke we observed higher plasma values of CRP, IL-1β, IL-6, TNF-α, E-Selectin, P-Selectin, ICAM-1, VCAM-1, wWF, PAI-1 in subjects with LAAS, lacunar and CEI subtype ischemic stroke and metabolic syndrome compared to subjects with this subtype of stroke without metabolic syndrome (see Table 2). The gene discussed is SERPINE1; the disease is Stroke.