TNF and Stroke: Among subjects with acute ischemic stroke we observed higher plasma values of CRP, IL-1β, IL-6, TNF-α, E-Selectin, P-Selectin, ICAM-1, VCAM-1, wWF, PAI-1 in subjects with LAAS, lacunar and CEI subtype ischemic stroke and metabolic syndrome compared to subjects with this subtype of stroke without metabolic syndrome (see Table 2).