In the present study, fasting lipid profile (with discrimination between lipids and lipoproteins fractions) was prospectively assessed in a cohort of patients with invasive carcinoma, in initial stages, before any treatment and with no history of being on antidiabetic or lipid lowering drugs (including statins, fibrates, oral antidiabetics, insulin or corticosteroids). Here, INS is linked to invasive carcinoma.