does not necessarily causes leukaemogenesis, but mass data show that BMI1 is crucial in leukaemic reprogramming collaborated with other partner contributing to the development of leukaemia, such as MLL-AF9, BCR-ABL, PLZF-RARA and even Runx1 mutation in clonal-disordered cells [27–30]. The gene discussed is BMI1; the disease is leukemia.