These observations can be related to data suggesting a role for this PG as a metastasis inhibitor; thus a highly metastatic variant of Lewis lung carcinoma cells displays low SDC2 expression, and this molecule is able to suppress activation of matrix metalloproteinase-2 (39); Furthermore, it has been described that osteosarcoma cells that overexpress SDC2 are restricted in their migration and also exhibit enhanced apoptosis in vitro (40). This evidence concerns the gene SDC2 and osteosarcoma.