GPC5 and neoplasm: The data obtained in the current work at the protein level demonstrating that high-grade tumors display epithelial differentiation are consistent with those previously described for lymphoma, where overexpression of this gene may contribute to the development and progression of the tumor (45), and rhabdomyosarcoma (primarily pediatric sarcomas resembling developing skeletal muscle) where GPC5 is upregulated and strongly associated with the appearance of and increase in cell proliferation (46).