These observations can be related to data suggesting a role for this PG as a metastasis inhibitor; thus a highly metastatic variant of Lewis lung carcinoma cells displays low SDC2 expression, and this molecule is able to suppress activation of matrix metalloproteinase-2 (39); Furthermore, it has been described that osteosarcoma cells that overexpress SDC2 are restricted in their migration and also exhibit enhanced apoptosis in vitro (40). This evidence concerns the gene MMP2 and Carcinoma, Lewis Lung.