Histology indicated the presence of fibroblasts and neovascularization within the AD graft, infiltrating from the matrix-dermis interface and not yet contacting the matrix-TE interface below, indicated by an asterisk (*) in Figure 1I. The immunohistochemistry of the soft tissue in the TE + AD group showed moderate presence of MMP-1 (Fig 1L, Table 3), with relatively little evidence of TIMP-1 (Table 3). Here, TIMP1 is linked to Alzheimer disease.