Two recently identified FMRP targets are striatal-enriched protein tyrosine phosphatase (STEP) and amyloid precursor protein (APP), which appear to underlie at least a portion of mouse Fmr1 phenotypes, as genetic reduction of either can suppress audiogenic seizure, anxiety, and social deficits in the disease model condition (Westmark et al., 2011; Goebel-Goody et al., 2012; Figure 2). Here, APP is linked to Anxiety.