Moreover, detailed analyses in SOD1-ALS mice also indicate that several pathological changes can be detected in interneurons, and importantly, much before the onset of disease symptoms (Martin et al., 2007; van Zundert et al., 2008, 2012; Ramírez-Jarquín et al., 2013; Wootz et al., 2013). Here, SOD1 is linked to amyotrophic lateral sclerosis.