Due to similarities in the pathologies of STGD3 and autosomal recessive Stargardt's disease (STGD1), it was proposed that VLC-PUFAs in the retina may influence the flippase activity by the ABCA4 protein, the STGD1 disease gene product (30). This evidence concerns the gene ABCA4 and severe early-childhood-onset retinal dystrophy.