Out of the initial sixteen FISH parameters chosen for evaluation, 10 were identified that detected FISH abnormalities in histologically benign ROIs of RP adenocarcinoma specimens, specifically CEP10%Abnormal, CEP10%Gain, CEP7%Abnormal, CEP7%Gain, CEP8%Abnormal, CEP8%Gain, MYC%Gain, LPL%Abnormal, PTEN%Loss, PTEN/CEP10%Loss. Here, PTEN is linked to adenocarcinoma.