In our study, AMACR was expressed by 57% (59/103) of all metastatic RCC, including 11 cases of metastatic CCRCC (34%, 11/32), all metastatic PRCCs (100%, 8/8), and 40 cases of RCC not previously classified (63%, 40/63). This evidence concerns the gene AMACR and nonpapillary renal cell carcinoma.