CD14 and Cowden disease: Although, therewas no association between G1359T variantand risk of CD, the TT genotype was more frequentin patients without HLA susceptibilityalleles compared with 180 normal volunteers.A recent Italian study on 938 CD patients and533 controls for investigating the role of threemajor CD14 polymorphisms (c.-1145A>G andc.-159C>T, c.-1359G>T) in CD has revealedthat only -1145A>G and -159C>T promotervariants had significant association with CD patientswho were either carriers of HLA DQ riskalleles or not (29).