In homozygousstate, the polymorphism has been thoughtto increase the activity of CYP1A1 enzyme (13).The current case-control study was conducted toexamine the hypothesis that ESR1-351(XbaI),ESR1-397(PvuII) and CYP1A1 (Ile462Val) polymorphismsare associated with the development ofuterine leiomyoma in female patients from Charmahaland Bakhtiari province of Iran. Here, ESR1 is linked to leiomyoma.