However, VEGFR2 plays a major role in transducingthe angiogenic effect of VEGF on tumor vasculature.Thus it is generally agreed that VEFGR2 on theendothelial cells is the major mediator of angiogenesisin solid tumors and has been an important receptorfor a number of anti-angiogenic agents in clinicalinvestigation. Here, VEGFA is linked to neoplasm.