Decreased expressionof MiR-15a/16 in MM contributes to proliferationand survival of MM cells with increasing activityof the Notch, c-jun and TP53 pathways (5, 73, 93).Increased expression of miR-17-92 is involved inanti-apoptotic signaling by decreasing Bim (90). This evidence concerns the gene JUN and Miyoshi myopathy.