There is a high prevalence of focal bonelesions in the patients who overexpress CCND1 (9).Increased expressions of miR-361-3p, miR-30e andmiR-582-5p have been observed in the t(11;14) translocation.The first two miRNAs target the PPP2R4gene, the activation of IL-6 signaling, and result inincreased growth and survival of myeloma cells(24). This evidence concerns the gene IL6 and plasma cell myeloma.