Decreased expression of MiR-146a and MiR-135b in t(4;14) translocation leads toincreases in expression of PELI2 and IRAK1 (IL-1 receptorassociated kinase) genes, which are involved inthe IL-1 signaling pathway, with an eventual increasein expression of IL-6 and MM cell growth (60). The gene discussed is IL6; the disease is Miyoshi myopathy.