CCL2 and ovarian carcinoma: Nieman and colleagues identified that omental adipocytes secrete IL-6, IL-8, chemokine (C-C motif) ligand 2 (CCL2), and tissue inhibitor of metalloproteinases-1, and that mAbs to each of these factors inhibited chemotaxis of ovarian cancer cells toward adipocytes by at least 50% (42).