Supporting this notion, the Slow Wallerian Degeneration (WldS) spontaneous mutant mice, overexpressing a chimeric protein that contains the full length NMNAT1 protein, display enhanced NAD+ availability and are protected against streptozotocin- and dietary-induced glucose intolerance in a SIRT1 dependent manner [124]. The gene discussed is SIRT1; the disease is Glucose intolerance.