Long et al. (2012) showed that long-term CBD enhanced social interaction in neuregulin-1 mutant mice (a putative animal model of schizophrenia – Long et al., 2012). Recently, our group showed that CBD was able to reverse the deficit in CFC presented by SHRs (Levin et al., 2012). Moreover, similar to the atypical antipsychotic clozapine (Robertson and Fibiger, 1992), CBD induced c-fos immunoreactivity in the nucleus accumbens (but not in the striatum) of rats (Guimaraes et al., 2004). This evidence concerns the gene FOS and schizophrenia.