This, and numerous other studies have characterized KCC2 as a transporter expressed exclusively in neurons of the CNS (reviewed by Blaesse et al., 2009), however some recent works showed also KCC2 expression in human fetal lens epithelial cell line (Lauf et al., 2008, 2012), chicken cardiomyocytes (Antrobus et al., 2012) and cancer cells (Wei et al., 2011) suggesting that functioning of KCC2 extends beyond the CNS. The gene discussed is SLC12A5; the disease is cancer.