SLC12A5 and ischemia: Currently there is a large number of observations describing a strong decrease in KCC2 expression in different pathologies, including temporal lobe epilepsies (Palma et al., 2006; Huberfeld et al., 2007; Bragin et al., 2009; Barmashenko et al., 2011), focal cortical dysplasia (Munakata et al., 2007; Shimizu-Okabe et al., 2011; Talos et al., 2012), ischemia (Galeffi et al., 2004; Papp et al., 2008; Jaenisch et al., 2010), as well as pathologies associated with different types of axonal injury (Coull et al., 2003; Shulga et al., 2008; Boulenguez et al., 2010).