Selective decrease in KCC2 mRNA has been observed during neurological disorders (Palma et al., 2006; Huberfeld et al., 2007), after sustained interictal-like activity (Rivera et al., 2004), and after axonal injury (Nabekura et al., 2002; Toyoda et al., 2003; Shulga et al., 2008, 2009). This evidence concerns the gene SLC12A5 and nervous system disorder.