SLC12A5 and nervous system disorder: Several recent reviews have provided detailed analysis of the KCC2, its expression profile, physiological roles and implications in different neurological disorders (e.g., Gamba, 2005; Medina and Chudotvorova, 2006; Kahle et al., 2008, 2013; Blaesse et al., 2009; Chamma et al., 2012; Gagnon and Delpire, 2013).