SLC12A5 and epilepsy: Impaired KCC2 activity and consequent increases of [Cl−]i have been documented in epilepsy (Palma et al., 2006; Huberfeld et al., 2007), neuropathic pain (Coull et al., 2003), and spasticity following spinal cord injury (Cramer et al., 2008; Shulga et al., 2008; Boulenguez et al., 2010).