IDO1 and temporal lobe epilepsy: Consistent with the induction of microglial IDO and KMO by proinflammatory cytokine signaling in a mouse model of temporal lobe epilepsy, hippocampal elevations in mRNA encoding IL-1β, TNF-α, IFN-γ, CD11b, IDO, and KMO were detected 24 h after kainic acid injection (Gleeson et al., 2010).