IDO1 and dementia: While the precipitating factors behind viral replication and kynurenine dysregulation may be similar, the neurocognitive dysfunction observed in HIV-associated neurocognitive disorder or dementia may be mediated in part by aberrant kynurenine metabolism in microglia within the brain in response to chronic production of proinflammatory cytokines, which one might speculate could be treated by inhibition of IDO, KMO, or KYNU.