TRAIL is an exciting anticancer molecule as it induces cell death in cancer cells without affecting healthy cells.6 Phase I clinical trials looking at the use of both recombinant TRAIL (rTRAIL)7 and monoclonal antibodies to the TRAIL death receptors, DR4 and DR5, have shown promising results.8, 9 However, there are problems with both of these treatment options. Here, TNFSF10 is linked to cancer.