IL-6 has been examined in AD with similar frequency as TNF-α, and with similar contradictory results [2, 28, 31, 34, 52–54, 58, 60, 61, 65, 67–69, 71, 75–77, 79, 87–89, 91, 92, 95–111]. The gene discussed is TNF; the disease is Alzheimer disease.