Moreover, Kuo and colleagues investigated the role of 2 non-synonymous SNPs (rs11549465 or Pro582Ser and rs11549467 or Ala588Thr) in coding region of HIF1A gene in NSCLC and found that patients carrying T/T genotype of rs11549465 or A/A genotype of rs11549467 had increased cancer risk compared with patients carrying other genotypes [31]. The gene discussed is HIF1A; the disease is cancer.