Thus, inhibition of mTOR/S6K1 activity may be an effective strategy for sensitizing cancer cells to apoptotic stimuli, and mTOR/S6K1-mediated downregulation of Mcl-1 is supposed to be responsible for the evodiamine-mediated enhancement of TRAIL-induced apoptosis in bladder cancer cells. The gene discussed is TNFSF10; the disease is urinary bladder cancer.