TNFSF12 and hyperinsulinemic hypoglycemia, familial, 4: For instance, sTWEAK may have a beneficial effect on the regulation of the immune response because it has been shown that TWEAK-deficiency in mice leads to overabundant natural killer cells and hypersensitivity to bacterial endotoxin, with an excess of interferon-γ and IL-12 production from innate immune cells.